Intraocular lenses (IOLs) are artificial lenses which can be used for changing the pure lens of the attention. Mostly, they’re used to exchange lenses which were clouded by cataracts. Roughly 30 million cataract surgical procedures had been carried out worldwide in 2022.1 Yearly this quantity will increase because of the rising prevalence of eye situations related to the getting old inhabitants, life-style modifications and different components.
A number of kinds of IOLs are used for cataract surgical procedure. Globally, cataracts are a significant contributor to visible impairment. In low and middle-income international locations, cataracts are accountable for over 50% of blindness circumstances.2 The most typical IOL is the monofocal IOL, which permits for focus at a hard and fast distance. Different kinds of IOLs, equivalent to multifocal and accommodative lenses, which permit the affected person to have completely different focusing powers inside the identical lens. Multifocal lenses have areas inside the lens that permit for viewing shut and distant objects. Accommodative lenses greatest simulate the pure lens of the attention by benefiting from the pure musculature of the attention to bodily change the refractive properties of the IOL.
As per the “World Intraocular Lens Market Worth, 2019-2029” chart, the multifocal IOL market compromised greater than half of the entire IOL market based mostly on the 2022 market worth.3 This pattern is anticipated to be noticed over the forecast interval, with the multifocal lens market gaining market shares annually. Regardless of this quick development, multifocal IOL items composed not more than 15% of the entire IOL items offered in 2022 globally. This disparity is because of the excessive common promoting value (ASP) of multifocal lenses.
In 2022, the ASP for multifocal IOLs had been nearly eight instances larger in comparison with monofocal IOLs.3 This can stay one of many predominant components limiting the excessive development of multifocal IOL over the forecast interval, regardless of its quite a few benefits. This text will focus on the primary driving components for the continued worldwide development of IOL.
Growing old of the Inhabitants Driving IOL Market Development
Worldwide development in IOL could be primarily attributed to the getting old of the inhabitants. As world healthcare has improved, the common lifespan of the inhabitants has expanded. Whereas this can be a constructive consequence, it additionally implies that people have the next chance of reaching an age the place they might encounter age-associated situations, equivalent to cataracts. Consequently, rise of an getting old inhabitants immediately correlates with the rising incidence fee of cataracts, together with the necessity to deal with it.
Frequent age-related eye situations embrace presbyopia, glaucoma, dry eyes, age-related muscular degeneration, cataracts and others. In response to the World Well being Group, at the very least 2.2 billion individuals have a close to or distance imaginative and prescient impairment with at the very least 1 billion of those circumstances being preventable.4 The principle situation inflicting distance imaginative and prescient impairment or blindness are cataracts, which impacts round 95 million individuals globally.4
Consequently, the necessity for reasonably priced and efficient therapy is crucial to scale back morbidity related to cataracts. Due to this fact, firms need to be ready to answer the rising demand for cataract surgical procedures.
Numerous main opponents within the IOL market are benefiting from this market development, in addition to some newer opponents which can be bringing novel know-how into the market. The principle opponents within the world IOL market are Alcon, J&J Imaginative and prescient Care, and Bausch & Lomb.
Elevated Incidence of Eye Situations
Globally, the prevalence variety of cataracts elevated by nearly 130% from 1990 to 2019.5 This may be attributed to a number of components. One such issue is life-style modifications. Particularly, elevated display screen time and publicity to digital gadgets contribute to earlier onset of imaginative and prescient issues which boosts the demand for IOL. Digital eye pressure (DES) encompasses a spread of ocular signs which come up from extended utilization of digital digital gadgets.
The COVID-19 pandemic’s lockdown measures curtailed outside actions for individuals of all ages, resulting in elevated display screen time. Primarily based on the statistics, the prevalence of DES signs in youngsters grew to 55%.6 Sure research point out that blue gentle publicity emitted by digital screens might induce oxidative stress inside the lens of the attention, doubtlessly taking part in a job within the improvement of cataracts. Oxidative stress arises when there may be an imbalance between the manufacturing of reactive oxygen species (ROS) and the physique’s capability to counteract them. This type of oxidative injury is believed to contribute to a spread of eye-related situations, together with the formation of cataracts.7 It is very important notice that there’s nonetheless plenty of debate on this subject as some research recommend that components apart from ultraviolet (UV) gentle publicity would possibly play a extra important function.
Prevalence of Diabetes
In 2021, each 1 in 10 adults was dwelling with diabetes, which accounts for greater than 520 million individuals.8 By 2045, this quantity is predicted to achieve 782 million in line with the Worldwide Diabetes Federation.8 People with diabetes have a notably elevated danger, starting from 2 to five time larger, of creating cataracts, which frequently manifest at an earlier stage of their lives.
There are a number of organic mechanisms that contribute to the elevated danger of creating cataracts. Mostly, elevated ranges of blood sugar in diabetes provoke a phenomenon often known as glycation, whereby surplus sugar molecules bind to proteins inside the lens of the attention.9 This interplay ends in a metamorphosis of the construction and performance of lens proteins, inducing a cloudy and fewer clear look. This opacity subsequently triggers the event of cataracts. Due to this fact, the rising prevalence of diabetes considerably impacts cataract surgical procedures.
Intraocular Lenses Analysis and Improvement
Because the demand for IOL rises annually, there are quite a few scientific analysis research aiming at enhancing the know-how. A particular space of analysis facilities on enhancing biocompatibility, reaching improved visible high quality and adjustability, minimizing surgical incisions and mitigating problems equivalent to posterior capsular opacification and ophthalmitis.10
Moreover, plenty of scientific analysis goals at advancing optics. This encompasses the creation of multifocal and accommodative IOLs, which permits people to realize readability of imaginative and prescient throughout completely different distances with out counting on eyeglasses. The customization of IOL is one other analysis space investigating customized IOLs to cater to the distinct visible necessities of every affected person, thereby optimizing their imaginative and prescient after surgical procedure. Furthermore, ongoing research are delving into IOLs which could be modified after being implanted, permitting for exact changes to refine the affected person’s visible acuity.11
Closing Factors
The worldwide intraocular lens market has been evolving and rising dramatically previously, and it’s anticipated to take care of development because the wants of the inhabitants enhance. With the excessive price of most biomaterials, North America and Western Europe characterize the very best proportion of the entire market. Moreso, IOLs are slowly changing into extra prevalent throughout the globe. Alcon stays the main firm available in the market worldwide.
For additional insights and extra granular market information, please see the report Ophthalmic Machine Market Dimension, Share, and Tendencies Evaluation – World – 2023-2029 by iData Analysis.
Concerning the Authors
Kateryna Hronska is a senior analysis analyst at iData Analysis. She works on analysis tasks relating to the medical machine trade, publishing the World Diagnostic and Interventional Ophthalmic Machine analysis report.
Kamran Zamanian, Ph.D., is CEO and founding companion of iData Analysis. He has spent over 20 years working available in the market analysis trade with a dedication to the research of medical gadgets used within the well being of sufferers everywhere in the globe.
About iData Analysis
For 19 years, iData Analysis has been a robust advocate for data-driven decision-making inside the world medical machine, dental, and pharmaceutical industries. By offering customized analysis and consulting options, iData empowers its shoppers to belief the supply of information and make essential strategic choices with confidence.
Citations
- Basaldua, B. (2023, March 3). The Way forward for Cataract Surgical procedure. iOR Companions | Workplace-Primarily based Surgical procedure.
- Tognetto, D., & Giglio, R. (2021, October 1). Synthetic Intelligence Functions and cataract administration: A scientific overview. Survey of Ophthalmology.
- iData Analysis Inc. World Diagnostic and Interventional Ophthalmic Machine Market – 2023. Revealed ___ 2023. Accessed ___, 2023.
- World Well being Group. (n.d.). Vision Impairment and blindness. World Well being Group.
- Fang, R., Yu, Y.-F., Li, E.-J., Lv, N.-X., Liu, Z.-C., Zhou, H.-G., & Tune, X.-D. (2022, November 12). World, regional, nationwide burden and gender disparity of cataract: Findings from the worldwide burden of illness research 2019 – BMC public well being. BioMed Central.
- Kaur, Ok., Gurnani, B., & Nayak, S. (2022, October). Digital Eye strain- A complete overview. Ophthalmology and remedy.
- Nita, M., & Grzybowski, A. (2016). The function of the reactive oxygen species and oxidative stress within the pathomechanism of the age-related ocular illnesses and different pathologies of the anterior and posterior eye segments in adults. Oxidative medication and mobile longevity.
- Diabetes all over the world in 2021. IDF Diabetes Atlas. (n.d.).
- Kiziltoprak, H., Tekin, Ok., & Inanc, M. (2019, March 15). Cataract in diabetes mellitus. World journal of diabetes.
- Luo, C., Wang, H., & Chen, X. (2022, Might 23). Current advances of intraocular lens supplies and floor modification in cataract surgical procedure. Frontiers.
- Salerno, L. C., Tiveron, M. C., & Alió, J. L. (2017). Multifocal intraocular lenses: Varieties, outcomes, problems and how you can clear up them. Taiwan journal of ophthalmology.
